
李庆刚,博士,569vip威尼斯游戏教授,博士生导师。天津市青年拔尖人才,中国轻工业微生物工程重点实验室副主任。
教学工作
主讲课程,工程生物学前沿讲座、微生物学;荣获569vip威尼斯游戏教学成果奖1项,指导本科生荣获省部级及校院级各类创新项目获奖多项。
科研领域及方向
[1] 功能糖、氨基酸等食药功能因子菌种构建
[2] 基于生物传感器的工业菌种高通量进化筛选
[3] 工业菌种发酵工程
科研项目情况
主持国家自然基金、绿色制造、863计划等国家级项目6项,主持省部级及企业横向项目近10项,近5年科研经费近千万,开发出高水平母乳寡糖、氨基酸等工业菌种,为企业新增加利润超过2亿元。
[1] 国家重点研发计划:绿色工业酶的高效表达系统构建与生产制备,2022-2025
[2] 国家自然科学基金面上项目:基于全细胞生物传感器的2′-岩藻糖基乳糖生产菌种高通量筛选方法开发及高产机制解析,2025-2028
[3] 国家自然科学基金面上项目:以异亮氨酰-tRNA合成酶为例构建一类新型氨基酸生物传感器,2019-2022
[4] 合成生物学海河实验室颠覆性创新(人才)类项目:人乳寡糖菌种高通量进化筛选体系构建,2022-2025
[5] 企业横向项目:人乳寡糖生产菌种研发,2021-2026
[6] 企业横向项目:有机酸及衍生物菌种高通量筛选技术开发,2022-2024
[7] 企业横向项目:太和豆豉系列产品发酵基理研究,2024-2027
主要学术成果
先后发表高水平SCI论文25篇,授权发明专利20余项。发表的主要学术论文有:
[1] Li Qinggang*, Liu Chuan, He Jinhuai, Liu Tiantian, Zhang Wencong, Xie Zhenzhen, Zong Jianfei, Li Yu, Sun Xue*, Lu Fuping. Construction and application of 3-fucosyllactose whole-cell biosensor for high-throughput screening of overproducers. Bioresource Technology. 2024, 402, 130798.
[2] Li Qinggang*, Ren Haojie, Liao Zhenjiang, Xia Shuchang, Xue Sun*. High throughput screening of transcription factor lysG for constructing a better lysine Biosensors. 2024, 14, 455.
[3] Li Dengke, Cai Yian, Guo Jiejie, Liu Yihan, Lu Fuping, Li Qinggang*, Liu Yexue*, Li Yu*. Screening signal peptidase based on split-GFP assembly technology to promote the secretion of alkaline protease AprE in Bacillus amyloliquefaciens. International journal of biological macromolecules, 2024, 269, 132166.
[4] Sun Xue, Peng Zetao, Li Chang, Zheng Yanling, Cheng Ya’nan, Zong Jianfei, Lu Fuping, Li Yu, Li Qinggang*. Combinatorial metabolic engineering and tolerance evolving of Escherichia coli for high production of 2'-fucosyllactose. Bioresource Technology. 2023, 372, 128667.
[5] Li Dengke, Guo Jiejie, Zhang Zhiqiang, Liu Yihan, Lu Fuping, Li Qinggang*, Liu Yexue*, Li Yu*. Sequence composition and location of CRE motifs affect the binding ability of CcpA protein. International journal of biological macromolecules. 2023, 253, 126407.
[6] Liu Yexue, Li Xueying, Liu Jiameng, Wei Likun, Liu Yihan, Lu Fuping, Wang Wenhang* , Li Qinggang*, Li Yu*. Focusing on Hofmeister series: Composition, structure and functional properties of pea protein extracted with food-related anions. Food Hydrocolloids. 2022,133, 107976.
[7] Zhang Jinfang, Zhu Baoyue, Xu Xiaojian, Liu Yihan*, Li Qinggang*, Li Yu*, Lu Fuping. Remodeling Bacillus amyloliquefaciens cell wall rigidity to reduce cell lysis and increase the yield of heterologous proteins. Journal of Agricultural and Food Chemistry. 2022, 70, 10552−10562.
[8] Sun, Xue†, Li, Qinggang†, Wang, Yu†, Zhou, Wenjuan, Guo, Yanmei, Chen, Jiuzhou, Zheng, Ping*, Sun, Jibin*, Ma, Yanhe. Isoleucyl-tRNA synthetase mutant based whole-cell biosensor for high-throughput selection of isoleucine overproducers., Biosensors and Bioelectronics. 2021, 172, 112783.
获奖及荣誉情况
荣获天津市青年拔尖人才称号,获批中国科学院青年创新促进会会员,入选天津市海河实验室人才项目。荣获内蒙古自治区科学技术进步一等奖,中国科学院科技促进发展奖,中国产学研合作创新成果奖。
联系方式
办公地点:天津经济技术开发区第十三大街29号569vip威尼斯游戏
邮政编码:300457
传 真:022-60602298
Email: liqinggang@tust.edu.cn